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Citric Acid Cycle - Overview of the Citric Acid Cycle
The Citric Acid Cycle is also known as the Krebs Cycle or Tricarboxylic Acid (TCA) Cycle. It is a series of chemical reactions that takes place in the cell that breaks down food molecules into carbon dioxide, water, and energy.
The citric acid cycle, also known as the Krebs cycle or tricarboxylic acid (TCA) cycle, is a series of chemical reactions in the cell that breaks down food molecules into carbon dioxide, water, and energy. In plants and animals, these reactions take place in the mitochondria of the cell as part of cellular respiration. Many bacteria perform the citric acid cycle too, though they do not have mitochondria so the reactions take place in the cytoplasm of bacterial cells. Sir Hans Adolf Krebs, a British biochemist, is credited with discovering the cycle. Sir Krebs outlined the steps of the cycle in 1937.
The overall reaction for the citric acid cycle is:
Acetyl-CoA + 3 NAD+ + Q + GDP + Pi + 2 H2O --> CoA-SH + 3 NADH + 3 H+ + QH2 + GTP + 2 CO2
where Q is ubiquinone and Pi is inorganic phosphate